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Subcutaneous administration of pegbelfermin over 16 weeks was generally well tolerated and significantly decreased hepatic fat fraction based on MRI in MASH subjects during a phase 2 study (NCT02413372)
Holter Monitor: If palpitations are sporadic, a Holter monitor may be prescribed
There was a possible increase in tibial BMD (ratio of BMC to area), but overall and vertebral BMDs might have remained consistent
Long-term data linking semaglutide-induced histologic changes to hard hepatic and cardiovascular outcomes are still needed
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